Historical buildings, which are important sources about the history, architectural features, social and cultural characteristics of the period in which they lived, have document value today by establishing a bridge between the past and the future.Restoration is one of the most basic areas of action of the conservation discipline, which aims to prot
In neuromorphic engineering, neural populations are generally modeled in a bottom-up manner, where individual neuron models are connected through synapses to form large-scale spiking networks.Alternatively, a top-down approach treats the process of spike generation and neural representation of excitation in the context of minimizing cent dyyni some
TP53 is the most frequently mutated gene in cancer.The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism and other processes.Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accelerated tumor progression.Mutant p53 often accumulates
Despite great efforts in the investigation, the exact etiology of amyotrophic lateral sclerosis (ALS) is a matter of intensive research.We recently advanced the idea that ALS might be caused by fungal infection.Indeed, fungal yeast and hyphal structures can be directly visualized in neural tissue of ALS patients, and a number of fungal species have